One trial conducted looked at the efficacy of either two doses of Pfizer, two of the Astra Zeneca, and one of the respect of each other. All the mixing worked well, boosting the immune system; the BBC stated the study was saying it on 28 June 2021.

A mixed-matching approach to covid-19 vaccines uses different vaccines for the first and second doses and gives good protection against the pandemic virus, a UK study has found.

92% of fully vaccinated HCWs who got Covid had mild infections' | India  News,The Indian Express

 The trial looked at the efficacy of two doses of Pfizer with two of AstraZeneca, respectively, by each other. The knowledge could offer flexibility for the vaccine roll-out, the report quoted, stated by experts.

The UK’s deputy chief medical officer Jonathan said there was no to change the current successful same doses of vaccine schedules in the UK, but given vaccines were in good supply and saving lives.

But he also added it might be something that we can look at in the future. Mixing the doses could provide us with even greater flexibility for a booster programme while also supporting the countries that have further to go with their vaccine, which may be experiencing supply difficulties. Two doses are essential to give complete protection and teach the body to make antibodies and T cells to block and kill the deadly virus.

Some of the countries are already using mixed doses. For example, Spain and Germany are offering the Pfizer or Moderna vaccines as the second dose to younger people who have already received a first dose of the AstraZeneca vaccine, seeing the concerns about a rare but serious blood clot, rather than efficacy.

The highest antibody response was seen after two Pfizer doses and the most increased T cell responses from Astra Zeneca and Pfizer.

The leading officer Prof Matthew Snape, from the University of Oxford, said the finding did not undermine the UK policy of giving people the same vaccine twice. We already know that both were schedules are very effective against severe disease and hospitalizations’, 

including against the Delta variant when given at eight to 12 weeks apart.

It may be effective, as the studies states.

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